Auditory Biochemistry and Molecular Biology Laboratory
Maria Angeles Vicente-Torres, Ph.D.
Research Fellow
Phone: (734) 764-5196
Fax: (734) 764-0014
E-mail: mavictor@mail.khri.med.umich.edu
Education
- Ph.D., chemical sciences (Biochemistry and Molecular Biology), Complutense University, Madrid, Spain, 1998
Accomplishments
- Researcher, Centre for Cell Culture, Complutense University, Madrid, Spain, 1997 - 2000
- Lecturer, undergraduate and graduate courses, Department of Surgery II, Faculty of Medicine, Complutense University, Madrid, Spain, 1994-2003
- Lecturer, postgraduate courses on Audiology, Nervous System and Cell Culture Techniques, 1994-2003
- Collaborator in seven scientific research contracts and grants, 1994-2003
Research Project
My research focuses on the study of the death / survival intracellular signalling pathways that are activated in response to noise exposure. I am analyzing two experimental situations: noise inducing a temporary threshold shift and noise inducing a permanent threshold shift. The project includes the study of the contribution of the different intracellular compartments to the apoptosis of the sensory hair cells, and therefore to hearing loss.
Publications
- Gil-Loyzaga P., Fernández-Mateos P., Vicente-Torres M.A., Remezal M., Cousillas H., Arce A., Esquifino A., (1993). Effects of noise stimulation on cochlear dopamine metabolism. Brain Research 623: 177-180.
- Vicente-Torres M.A., Gil-Loyzaga P., Fernández-Mateos P. Arce A., Esquifino A. (1993). Piribedil could modify dopamine turnover in cochleas under noise stimulation. Journal of Otorhinolaryngoly and its Related Specialities 55: 322-324.
- Gil-Loyzaga P., Vicente-Torres M.A., Fernández-Mateos P. Arce A., Esquifino A. (1994). Piribedil affects dopamine turnover in cochleas stimulated by white noise. Hearing Research 79: 178-182.
- Gil-Loyzaga P., Vicente-Torres M.A., García-Bonacho M., Esquifino A. (1997). Presence of catecholamines and serotonin in the rat vestibule. Brain Research 746: 265-268.
- Gil-Loyzaga P., Bartolomé M.V., Vicente-Torres M.A. (1997). Serotonergic innervation of the organ of Corti of the cat cochlea. NeuroReport 8: 3519-3522.
- Vicente-Torres M.A., Bartolomé Pascual M.V., Hernández Martínez E., Carricondo Orejana F., Ibáñez Olías M.A. (1997). Cultivo de células y tejidos animales. Teoría y prácticas (Culture of animal cells and tissues. Theory and practice). Ed: P. Gil-Loyzaga. Centro de Cultivos Celulares (CAI-UCM), Madrid, pp. 1-170.
- Gil-Loyzaga P., Vicente-Torres M.A., Arce A., Cardinali D., Esquifino A. (1998). Effect of superior cervical ganglionectomy on catecholamine concentration in rat cochlea. Brain Research 779: 53-57.
- Vicente-Torres M.A., Bartolomé M.V., Carricondo F., Esquifino A., Gil-Loyzaga P. (1998). HPLC detection of serotonin within the cochlea of the rat. NeuroReport 9: 3699-3701.
- Esquifino A., Arce A., Vicente-Torres M.A., Gil-Loyzaga P. (1998). Effects of acute and chronic administration of cyclosporine on dopamine metabolism in the rat cochlea. Journal of Physiology and Biochemistry 54: 149-154.
- Gil-Loyzaga P., Poch-Broto J., Vicente-Torres M.A., Bartolomé M.V., Carricondo F., San Román J., Jiménez L. (1999). GABA, dopamine and serotonin in cochlear innervation. Models of protection against neurotoxicity. In: Cochlear pharmacology and noise trauma, D. Prasher and B. Canlon (Eds.), NRN Publications, London. pp. 23-42.
- Vicente-Torres M.A., Gil-Loyzaga P. (1999). Noise stimulation decreases the concentration of norepinephrine in the rat cochlea. Neuroscience Letters 266: 217-219.
- Moreno Sierra J., Redondo González E., Vicente-Torres M.A., Bartolomé M., Gil-Loyzaga P., Resel Estévez L. (1999). Desarrollo de cultivos celulares en la investigación básica del carcinoma renal (Development of cell cultures in basic research of kidney carcinome) . Urología Oncológica 52: 133-139.
- Gil-Loyzaga P., Bartolomé M., Vicente-Torres M.A., Carricondo F. (2000). Serotonergic innervation of the organ of Corti. Acta Otolaryngologica (Stockholm) 120: 128-132.
- Vicente-Torres M.A., Muñoz E, Davila D, Gil-Loyzaga P. (2001). Changes in the cochlear dopaminergic system of the aged rat. Brain Research 917: 112-117.
- Carricondo F., Bartolomé MV., Vicente-Torres M.A., Fernández Pacheco P., Rodriguez MT., Gil-Loyzaga P. (2002). Sensitivity to glutamate neurotoxicity in different developmental periods of the rat cochlea. Advances in Oto-Rhino-Laryngology 59: 91-95.
- Vicente-Torres M.A., Davila D, Muñoz E, Gil-Loyzaga P. (2002). Effects of aging on cochlear monoamine turnover. Advances in Oto-Rhino-Laryngology 59: 112-115.
- Vicente-Torres M.A., Gil-Loyzaga P. (2002). Age- and gender-related changes in the cochlear sympathetic system of the rat. Neuroscience Letters 319: 177-179.
- Vicente-Torres M.A., Gil-Loyzaga P., Carricondo F., Bartolomé M.V. (2002) Simultaneous HPLC quantification of monoamines and metabolites in the blood-free rat cochlea. Journal of Neuroscience Methods 119 : 31-36.
- Vicente-Torres M.A., Dávila D., Bartolomé M.V., Carricondo F., Gil-Loyzaga P. (2003) Biochemical evidence for the presence of serotonin transporters in the rat cochlea. Hearing Research 182: 44-47.
- Bartolomé M.V., Vicente-Torres M.A., Carricondo F., Gil-Loyzaga P. (2003) El sistema auditivo como base de la comprensión del lenguaje (The auditory system as basis of the language understanding). Boletín de la Asociación Española de Logopedas, Foniatras y Audiologos 2: 16-19.
