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Auditory Biochemistry and Molecular Biology Laboratory

Publications

Quick Jump:

• Regulatory Mechanisms in the Inner Ear
• Drug-induced Hearing Loss
• Noise-induced Hearing Loss
• Other Topics of Auditory Biochemistry and Pathophysiology
• History

Regulatory Mechanisms in the Inner Ear

Chapters and Reviews

• Talaska, A.E. and Schacht, J. Homeostatic stress response pathways. In: Meniere's Disease and Inner Ear Homeostasis Disorders (Lim, D. J., ed.). House Ear Institute, Los Angeles, CA, pp. 1-3, 2005.
• Jiang, H, Sha, S-H and Schacht, J. Second Messengers in the inner ear (in Chinese). In: Bases and Clinics of Deafness. Xie, D., ed. Hunan Sci. Techn. Press, Wuhan, PR China, pp. 66-74, 2004.
• Zhao, L-D., Li, X-Q. and Schacht, J. The role of "supporting cells" in the cochlea. Korean J. Otolaryngol. 45:1120-1124, 2002. - if you read Korean.
• Fessenden, J.D. and Schacht, J. The nitric oxide/cyclic GMP pathway: A potential major regulator of cochlear physiology. Hear. Res. 118:168-176, 1998.
• Wangemann, A.P. and Schacht, J. Homeostatic mechanisms in the cochlea. In: Handbook of Auditory Research (Fay, R.R. and Popper, A.N., eds), Vol IX: The Cochlea (Dallos, P., ed). Springer, New York, pp. 130-185, 1996.
• Coling, D.E. and Schacht, J. Second messengers in the cochlea. Acta Otolaryngol 115:218-221, 1995.
• Schacht, J., Fessenden, J.D and Zajic, G. Slow motility of outer hair cells. In: Active Hearing (Å. Flock, D. Ottoson, M. Ulfendahl, eds), Elsevier Science, Oxford, pp. 209-220, 1995.

Original Articles

• Jiang, H., Sha S-H. and Schacht, J. Rac/Rho pathway regulates actin depolymerization induced by aminoglycoside antibiotics. J. Neurosci. Res. 83:1544-1551, 2006. doi: 10.1002/jnr.20833
• Chung, J.W. and Schacht, J. ATP and nitric oxide modulate intracellular calcium in isolated pillar cells of the guinea pig cochlea. JARO 2:399-407, 2001.
• Matsunobu, T. and Schacht, J.Acetylcholine-evoked calcium increases in Deiters' cells of the guinea pig cochlea suggest a9-like receptors. J. Neurosci. Res. 63:252-256, 2001.
• Matsunobu, T. and Schacht, J. The nitric oxide/cyclic GMP pathway attenuates ATP-evoked intracellular calcium increase in supporting cells of the guinea pig cochlea. J. Comp. Neurol. 423:452-461, 2000.
• Fessenden, J.D., Altschuler, R.A., Seasholtz, A.F. and Schacht, J. Nitric oxide/cyclic guanosine monophosphate pathway in the peripheral and central auditory system of the rat. J. Comp. Neurol. 404:52-63, 1999.
• Tian, F., Fessenden, J.D. and Schacht, J. Cyclic GMP-dependent protein kinase-I in the guinea pig cochlea. Hear. Res. 131:63-70, 1999.
• Puschner, B. and Schacht, J. Energy metabolism in cochlear outer hair cells in vitro. Hear. Res. 114:102-106, 1997.
• Fessenden, J.D. and Schacht, J. Distribution of soluble guanylate cyclase activity suggests regulation of blood flow and supporting cell physiology in the inner ear. J. Histochem. Cytochem. 45:1401-1408, 1997.
• Puschner, B. and Schacht, J. Calmodulin-dependent protein kinases mediate calcium-induced slow motility of mammalian outer hair cells. Hear. Res. 110:251-258, 1997.
• Ogawa, K. and Schacht, J. P2y purinergic receptors coupled to phosphoinositide hydrolysis in tissues of the cochlear lateral wall. Neuroreport 6:1538-1540, 1995.
• López-Escámez, J.A. and Schacht, J. Mechanically induced calcium increases in isolated vestibular hair cells of the guinea pig. Acta Otolaryngol. 115:759-764, 1995.
• Fessenden, J.D., Coling, D.E. and Schacht, J. Detection and characterization of nitric oxide synthase in the mammalian cochlea. Brain Res. 668:9-15, 1994.
• Ogawa, K. and Schacht, J. G-proteins coupled to phosphoinositide hydrolysis in the cochlear and vestibular epithelia of the rat are insensitive to cholera and pertussis toxins. Hear. Res. 74:197-203, 1994.
• Ogawa, K. , McLaren, J and Schacht, J. Effect of aging on myo-inositol and phosphoinositide metabolism in the cochlear and vestibular sensory epithelia of the rat. Hear. Res. 73:155-162, 1994.
• Coling, D., Naik, R. and Schacht, J. Calcium and calmodulin inhibit phosphorylation of a novel auditory nerve protein. Hear. Res. 72:197-205, 1994.
• Ogawa, K. and Schacht, J. Receptor-mediated release of inositol phosphates in the cochlear and vestibular sensory epithelia of the rat. Hear. Res. 69:207-214, 1993.
• Niedzielski, A.S., Ono, T. and Schacht, J. Cholinergic regulation of the phosphoinositide second messenger system in the organ of Corti. Hear. Res. 59:250-254, 1992.
• Niedzielski, A.S. and Schacht, J. P2 purinoceptors stimulate inositol phosphate release in the organ of Corti. Neuroreport 3:273-275, 1992.
• Pujol, R., Zajic, G., Dulon, D., Raphael, Y., Altschuler, R.A. and Schacht, J. First appearance and development of motile properties in outer hair cells isolated from guinea pig cochlea. Hear. Res. 57:129-141, 1991.
• Coling, D.E. and Schacht, J. Protein phosphorylation in the Organ of Corti: Differential regulation by second messengers between base and apex. Hear. Res. 57:113-120, 1991.
• Niedzielski, A.S. and Schacht, J. Phospholipid metabolism in the cochlea: Differences between base and apex. Hear. Res. 57:107-112, 1991.
• Zajic, G. and Schacht, J. Shape changes in isolated outer hair cells: measurements with attached microspheres. Hear. Res. 52:407-410, 1991.
• Dulon, D., Zajic, G. and Schacht, J. Differential motile response of isolated inner and outer hair cells to stimulation by potassium and calcium. Hear. Res. 52:225-231, 1991.
• Wang, S. and Schacht, J. Insulin stimulates protein synthesis and phospholipid signaling systems but does not regulate glucose uptake in the inner ear. Hear. Res. 47:53-62, 1990.
• Bobbin, R.P., Fallon, M., Puel, J-L., Bryant, G., Bledsoe, S.C., Zajic, G. and Schacht, J. Acetylcholine, carbachol, and GABA induce no detectable change in the length of isolated outer hair cells. Hear. Res. 47:39-52, 1990.
• Dulon, D., Zajic, G. and Schacht, J: Increasing intracellular free calcium induces circumferential contractions in isolated outer hair cells. J. Neurosci. 10:1388-1397, 1990.

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Drug-induced Hearing Loss

Chapters and Reviews

• Talaska, A.E. and Schacht, J. Współczesne spojrzenie na uszkodzenia słuchu spowodowane lekami. Otorynolaryngologia 5:7-12, 2006.

You don't read Polish? How about this one:

• Talaska, A.E. and Schacht, J. Avances en el conocimiento de la ototoxicidad. Suplementos de Actualización en ORL 1:38-43, 2005.

Nada? Is this better:

• Schacht, J. Erworbene Schwerhörigkeit - protektive Maßnahmen. In: Hören und Gene (von Specht, H., ed.), Geers-Stiftung, Essen, Schriftenreihe Vol. 15, pp. 97-108, 2005.

Still not happy?

• Talaska, A.E. and Schacht, J. Prevention of aminoglycoside ototoxicity: From the laboratory to the clinic. Volta Rev. 105:371-383, 2005.
• Sha, S-H, Jiang, H., Wu, W., Xie, D. and Schacht, J. Ototoxicity (in Chinese). In: Bases and Clinics of Deafness. Xie, D., ed. Hunan Sci. Techn. Press, Wuhan, PR China, pp. 231-245, 2004.

If you don't read Chinese, you will like the next one:

• Lautermann, J., Dehne, N., Schacht, J. and Jahnke K. Aminoglykosid- und Cisplatin-Ototoxizität: von der Grundlagenforschung zur Klinik. Laryngo-Rhino-Otol. 83:317-323, 2004.
• Schacht, J. Mechanisms for Aminoglycoside Ototoxicity: Basic Science Research. In: Ototoxicity, Roland, P.S. and Rutka, J.A., eds. BC Decker Inc., Hamilton, pp.93-100, 2004.
• Sha S-H and Schacht J. Chelators and antioxidants prevent aminoglycoside-induced hearing loss. Biomark. Envir. 5:8-9, 2004.
• Steyger, P.S., Fekete, D.M., Heller, S., Schacht, J. and Yamoah, E.N. Research trends in cochlear development, physiology, dysfunction and bio-medical interventions. In: 2004 Summit on Deafness, A.G. Bell Society, Washington DC, pp. 5-7, 2004.
• Lautermann, J., Schacht, J. and Jahnke K. Aminoglykosidototoxizität. Pathomechanismen, Klinik und Präventionsmöglichkeiten. HNO 51:344-352, 2003.
• Kettle, A. and Schacht, J. Antioxidant therapy: a promising approach to the prevention of noise- and drug-induced hearing loss. Korean J. Otolaryngol. 45:931-935, 2002.
• Forge, A. and Schacht, J. Aminoglycoside antibiotics. Audiol. Neuro-Otol. 5:3-22, 2000.
• Sha, S-H., Gao, Q-X., Li, X-Q., Jiang, S-C. and Schacht, J. Advances in mechanism and prevention of aminoglycoside ototoxicity (in Chinese). J. Audiol. Speech Pathol. 9:180-182, 2001.
• Sha, S.-H. and Schacht, J. Mechanism and prevention of aminoglycoside-induced hearing loss. In: Cell and Molecular Biology of the Ear (Lim, D.J., ed), Plenum Press, New York, NY, pp.157-164, 2000.
• Schacht, J. and Sha, S.-H. Interventions to prevent aminoglycoside-induced hearing loss. Proc. 15th Internat. SHHH Conv., pp. 3-5, 2000.
• Schacht, J. Antioxidant therapy: A promising approach to the prevention of aminoglycoside-induced hearing loss. Ned. Tijdschr. KNO-Heelk. 5:30-32, 1999.
• Schacht, J. Antioxidant therapy attenuates aminoglycoside-induced ototoxicity. Ann. N.Y. Acad. Sci. 884:125-130, 1999.
• Schacht, J. Biochemistry and pharmacology of aminoglycoside-induced hearing loss. Acta Physiol. Pharmacol. Ther. Latinoamer. 49:251-256, 1999.
• Schacht, J. Aminoglycoside ototoxicity: Prevention in sight? Otolaryng. Head Neck Surg. 118:674-677, 1998.
• Sha, S.-H. and Schacht, J. Drug-induced hearing loss: how can it be prevented? Hear. Loss J. 19:14-18, 1998.
• Arkaravichien, W. and Schacht, J. Drug-induced hearing loss: A worldwide problem. Int. Med. J. 4:243-251, 1997.
• Sha, S-H. and Schacht, J. Prevention of aminoglycoside-induced hearing loss. Keio J. Med. 46:115-119, 1997
• Priuska, E. and Schacht, J. Mechanism and prevention of aminoglycoside ototoxicity: Outer hair cells as targets and tools. Ear Nose Throat J. 79: 164-171, 1997.
• Garetz, S.L. and Schacht, J. Ototoxicity: Of Mice and Men. In: Handbook of Auditory Research (Fay, R.R. and Popper, A.N., eds), Vol. VII: Clinical Aspects of Hearing (VanDeWater, T.R., Popper, A.N. and Fay, R.R., eds), Springer-Verlag, New York, pp. 116-154, 1996.
• Schacht, J. Biochemical basis of aminoglycoside ototoxicity. In: Otolaryngologic Clinics of North America, Vol. 26 (Rybak, L.P., ed); W.B.Saunders, Philadelphia, pp. 845-856, 1993.
• Schacht, J. Gentamicin-Schäden des Innenohres. Med-Report 16:3, 1992.
• Huang, M.Y. and Schacht, J. Drug-induced ototoxicity. Curr. Therap. 32:71-73, 1991.

Original Articles

• Sha, S-H., Qiu, J-H. and Schacht, J. Aspirin to prevent gentamicin-induced hearing loss. New Engl. J. Med. 354:1856-1857, 2006.
• Jiang, H., Sha S-H. and Schacht, J. Rac/Rho pathway regulates actin depolymerization induced by aminoglycoside antibiotics. J. Neurosci. Res. 83:1544-1551, 2006. doi: 10.1002/jnr.20833
• Jiang, H., Sha, S-H., Forge, A. and Schacht, J. Caspase-independent pathways of hair cell death induced by kanamycin in vivo. Cell Death Diff. 13:20-30, 2006. doi: 10.1038/sj.cdd.4401706
• Lesniak, W., Pecoraro, V-L., and Schacht, J. Ternary complexes of gentamicin with iron and lipid catalyze formation of reactive oxygen species. Chem. Res. Toxicol. 18:357-364, 2005.
• Jiang, H., Sha, S-H. and Schacht, J. The NF-ϰB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity. J. Neurosci. Res. 79:644-651, 2005.
• Minami, S.B., Sha, S-H. and Schacht, J. Antioxidant protection in a new animal model of cisplatin-induced ototoxicity. Hear. Res. 198:137-143, 2004.
• Kawamoto, K, Sha, S-H, Minoda, R, Izumikawa, M, Kuriyama, H, Schacht, J and Raphael, Y. Antioxidant gene therapy can protect hearing and hair cells from ototoxicity. Molec. Ther. 9:173-181, 2004.
• Lesniak W, Harris WR, Kravitz JY, Schacht J and Pecoraro V (2003) Solution chemistry of copper(II)-gentamicin complexes: Relevance to metal-related aminoglycoside toxicity. Inorg. Chem. 42:1420-1429, 2003.
• Lesniak, W., McLaren J., Harris, W.R., Pecoraro, V.L. and Schacht, J. An isocratic separation of underivatized gentamicin components, 1H NMR assignment and protonation pattern. Carbohydr. Res. 338:2863-2862, 2003.
• Wu, W-J., Sha, S-H. and Schacht, J. Recent advances in understanding aminoglycoside ototoxicity and its prevention. Audiol. Neuro-Otol. . 7:171-174, 2002.
• Wang, A-M., Sha, S-H., Lesniak, W. and Schacht, J. Tanshinone (Salviae miltiorrhizae extract) preparations attenuate aminoglycoside-induced free radical formation in vitro and ototoxicity in vivo. Antimicrob. Agents Chemother. 47:1836-1841, 2003.
• Li, G., Sha, S-H., Zotova, E., Arezzo, J., Van De Water, T. and Schacht, J. Salicylate protects hearing and kidney function from cisplatin (CDDP) toxicity without compromising its oncolytic action. Lab. Invest. 82:585-596, 2002.
• Wu, W-J., Sha, S-H., McLaren, J.D., Kawamoto, K., Raphael, Y. and Schacht, J. Aminoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague-Dawley rat. Hear. Res. 158:165-178, 2001.
• Sha, S-H., Zajic, G., Epstein CJ and Schacht, J. Overexpression of SOD protects from kanamycin-induced hearing loss. Audiol. Neuro-Otol. 6:117-123, 2001.
• Sha, S-H., Taylor, R., Forge, A. and, Schacht, J. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear. Res. 155:1-8, 2001.
• Gilmartin, M. R., McLaren, J. and Schacht, J. Confounding factors in lanthanide ion probe spectrofluorimetric assays of aminoglycoside antibiotics. Anal. Biochem. 283:116-119, 2000.
• Sinswat, P., Wu, W-J., Sha, S-H. and Schacht, J. Protection from ototoxicity of intraperitoneal gentamicin in guinea pig. Kidney Int. 58:2525-2532, 2000.
• Sha, S.H. and Schacht, J. Antioxidants attenuate gentamicin-induced free-radical formation in vitro and ototoxicity in vivo: D-methionine is a potential protectant. Hear. Res. 142:34-40, 2000.
• Sha, S-H. and Schacht, J. Salicylate attenuates gentamicin-induced ototoxicity. Lab. Invest. 79:807-813, 1999.
• Sha, S-H. and Schacht, J. Formation of reactive oxygen species following bioactivation of gentamicin. Free Radical Biol. Med. 26:341-347, 1999.
• Sha, S-H. and Schacht, J. Formation of free radicals by aminoglycoside antibiotics. Hear. Res. 128:112-118, 1999.
• Priuska, E.M., Clark, K., Pecoraro, V. and Schacht, J. NMR spectra of iron-gentamicin complexes and the implications for aminoglycoside toxicity. Inorg. Chim. Acta 273:85-91, 1998.
• Song, B-B., Sha, S-H. and Schacht, J. Iron chelators protect from aminoglycoside-induced cochleo- and vestibulotoxicity in guinea pig. Free Radical Biol. Med. 25:189-195, 1998.
• Sha, S-H. and Schacht, J. Are aminoglycoside antibiotics excitotoxic? NeuroReport 9:3893-3895, 1998.
• Song, B.-B., Anderson, D.J. and Schacht, J. Protection from gentamicin ototoxicity by iron chelators in guinea pig in vivo. J. Pharmacol. Exp. Ther. 282:369-377, 1997.
• Vardhanabhuti, N., Ramachandran, Ch., Schacht, J. and Weiner, N. Preparation of liposomes with asymmetric distribution of phosphatidylinositol 4,5-bisphosphate across the bilayer. J. Liposome Res. 7:301-314, 1997.
• Ryals, B., Westbrook, E. and Schacht, J. Morphological evidence of ototoxicity of the iron chelator deferoxamine. Hear. Res. 112:44-48, 1997.
• Lautermann, J., Crann S.A., McLaren, J. and Schacht, J. Glutathione-dependent antioxidant systems in the mammalian inner ear: effects of aging, ototoxic drugs and noise. Hear. Res. 114:75-82, 1997.
• Crann, S.A. and Schacht, J. Activation of aminoglycoside antibiotics to cytotoxins. Audiol Neuro-Otol 1:80-85, 1996.
• Song, B-B. and Schacht, J. Variable efficacy of radical scavengers and iron chelators to attenuate gentamicin ototoxicity in guinea pig in vivo. Hear. Res. 94:87-93, 1996.
• Lautermann, J. and Schacht, J. A sensitive animal model to assess acute and chronic otovicity. Arch Ototoxicity Head Neck Surg. 122:837-840, 1996.
• Priuska, E. and Schacht, J. Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex. Biochem. Pharmacol. 50:1749-1752, 1995.
• Lautermann, J. and Schacht, J. Reduzierter Ernährungszustand verstärkt Ototoxizität. Laryngo-Rhino-Otologie 74:724-727, 1995.
• Lautermann, J., Song, B., McLaren, J. and Schacht, J. Diet is a risk factor in cisplatin ototoxicity. Hear. Res. 88: 47-53, 1995.
• Lautermann, J., McLaren, J. and Schacht, J. Glutathione protection against gentamicin ototoxicity depends on nutritional status. Hear. Res. 86: 15-24, 1995.
• Garetz, S.L., Altschuler, R.A. and Schacht, J. Attenuation of gentamicin ototoxicity by glutathione in the guinea pig in vivo. Hear. Res. 77:81-87, 1994.
• Garetz, S.L., Rhee, D.J. and Schacht, J. Sulfhydryl compounds and antioxidants inhibit cytotoxicity to outer hair cells of a gentamicin metabolite in vitro. Hear. Res. 77:75-80, 1994.
• El Barbary, A., Altschuler, R. and Schacht, J. Glutathione S-transferase in the organ of Corti of the rat: enzymatic activity, subunit composition and immunohistochenical localization. Hear. Res. 71:80-90, 1993.
• Crann, S.A., Huang, M.Y., McLaren, J.D. and Schacht, J. Formation of a toxic metabolite from gentamicin by a hepatic cytosolic fraction. Biochem. Pharmacol. 43:1835-1839, 1992.
• Huang, M.Y. and Schacht, J. Formation of a cytotoxic metabolite from gentamicin by liver. Biochem. Pharmacol. 40:R11-R14, 1990.

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Noise-induced Hearing Loss

Chapters and Reviews

• Le Prell, C., Dolan, D., Schacht, J., Miller, J. M., Lomax, M. and Altschuler RA. Pathways for protection from noise-induced hearing loss. Noise Health 5:1-18, 2003.
• Miller, J., Schacht, J., Altschuler, R. Prevention of noise-induced hearing loss. In: Noise Induced Hearing Loss: Basic Mechanisms, Prevention and Control (Henderson D, Prasher D, Kopke R, Salvi R and Hamernik R, eds), Noise in Network Publications, London, UK, pp. 215-230, 2001.
• Altschuler RA, Raphael Y, Schacht J, Anderson DJ and Miller JM. Protection and Repair of Hearing. In: Principles of Tissue Engineering (Lanza RP, Langer R Vacanti J, editors), Second Edition, Academic Press, San Diego, CA, pp. 751-760, 2000.
• Altschuler, R.A., Miller, J.M., Raphael, Y. and Schacht, J. Strategies for protection of the inner ear from noise-induced hearing loss. In: Cochlear Pharmacology and Noise Trauma (Prasher, D. and Canlon B., eds), NRN Publications, London; pp. 98-107, 1999.

Original Articles

• Vicente-Torres, M.A. and Schacht, J. A BAD link to mitochondrial cell death in noise-induced hearing loss. J. Neurosci. Res. 83:1564-1572, 2006. doi: 10.1002/jnr.20832
• Yamashita, D., Jiang, H-Y., Schacht, J. and Miller, JM. Post-exposure treatment attenuates noise-induced hearing loss. Neuroscience 134: 633-642, 2005. doi: 10.1016/j.neuroscience.2005.04.015
• Yamashita, D., Jiang, H-Y., Schacht, J. and Miller, JM. Delayed production of free radicals following noise exposure. Brain Res. 1019:201-109, 2004.
• Minami, S.B., Yamashita, D., Schacht, J. and Miller, J.M. Calcineurin activation contributes to noise-induced hearing loss. J Neurosci. Res. 78:383-392, 2004.
• Yamashita, D., Miller, J.M., Jiang, H., Minami, S.B. and Schacht, J. AIF and EndoG in noise-induced hearing loss. Neuroreport 15:2719-2722, 2004.
• Endo T., Nakagawa, T., Iguchi, F., Kita, T., Okano, T., Sha S-H., Schacht, J., Shiga, A., Kim, T-S. and Ito, J. Elevation of superoxide dismutase increases acoustic trauma from noise exposure. Free Rad. Biol. Med. 38:492-498, 2005.
• Matsunobu, T., Ogita, K. and Schacht, J. Modulation of AP-1 / DNA binding activity by acoustic overstimulation in the guinea pig cochlea. Neuroscience 123:1037-1043, 2004.
• Brown, N., Miller, J.M. and Schacht, J (2003) 8-iso-prostaglandin F2, a product of noise exposure, reduces inner ear blood flow. Audiol. Neuro-Otol. 8:207-221, 2003.
• Ohinata Y, Miller JM and Schacht J. Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea. Brain Res. 966:265-273, 2003.
• Ohinata, Y., Miller, J.M., Altschuler, R.A. and Schacht, J. Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea. Brain Res. 878:163-173, 2000.
• Ohinata, Y., Yamasoba, T., Schacht, J. and Miller J.M. Glutathione limits noise-induced hearing loss. Hear. Res. 146:28-34, 2000.
• Ogita, K., Matsunobu, T. and Schacht, J. Acoustic stimulation enhances DNA binding of transcription factor AP-1 in the guinea pig inner ear. NeuroReport 11:859-862, 2000.
• Yamasoba T., Schacht J., Shoji F., Miller J.M. Attenuation of cochlear damage from noise trauma by an iron chelator, a free radical scavenger and glial cell line-derived neurotrophic factor in vivo. Brain Res. 815:317-325, 1999.

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Other Topics of Auditory Biochemistry and Pathophysiology

• Sharashenidze, N., Shakhti, I. and Qevanishvili, Z. Presbyacusis: Age-related hearing loss (in Georgian). Exp. Clin. Medicine. 5-6:64-69
• Lamm, K., Zajic, G. and Schacht, J. Living isolated cells from inner ear vessels: a new approach for studying the regulation of cochlear microcirculation and vascular permeability. Hear. Res. 81:83-90, 1994.
• Schwartz, D.R., Schacht, J., Miller, J.M., Frey, K. and Altschuler, R. Chronic electrical stimulation reverses deafness-related depression of electrically evoked 2-deoxyglucose activity in the guinea pig inferior colliculus. Hear. Res. 70:243-249, 1993.
• Zajic, G., Forge, A. and Schacht, J. Membrane stains as an objective means to distinguish isolated inner and outer hair cells. Hear. Res. 66:53-57, 1993.
• Forge, A., Zajic, G., Li, L., Nevill, G. and Schacht, J. Structural variability of the sub-surface cisternae in intact, isolated outer hair cells shown by fluorescent labelling of intracellular membranes and freeze-fracture. Hear. Res. 64:175-183, 1993.
• Crann, S.A., Van De Water, T.R. and Schacht, J. Ornithine decarboxylase activity during development of the mouse inner ear in vivo and in vitro. Cell Tissue Res. 265:547-550, 1991.
• Ptok, M., Nair, T.S., Altschuler, R.A., Schacht, J. and Carey, T.E. Monoclonal antibodies to inner ear antigens: II. Antigens expressed in sensory cell stereocilia. Hear. Res. 57:79-90, 1991.
• Zajic, G., Nair, T.S., Ptok, M., Van Waes, C., Altschuler, R.A., Schacht, J. and Carey, T.E. Monoclonal antibodies to inner ear antigens: I. Antigens expressed by supporting cells of the guinea pig cochlea. Hear. Res. 52:59-71, 1991.
• Robbins, J.A. and Schacht, J. Ageing - a contagious disease. J. Irrep. Res. 36:8-9, 1991.

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History

These historical articles are part of a series of "Sketches in Otohistory" conceived by Dr. Joseph Hawkins and published in the journal "Audiology & Neurotology". See What's New? for a complete listing and information on how to access the papers.

• Schacht, J. and Hawkins, J.E. Sketches of Otohistory. Part 4: A cell by any other name: cochlear eponyms. Audiol. Neuro-Otol. 9:317-327, 2004. doi: 10.1159/000081311
• Hawkins, J.E. and Schacht, J. Sketches of Otohistory. Part 7: The nineteenth-century rise of laryngology. Audiol. Neurotol. 10:130-133, 2005. doi: 10.1159/000084022
• Hawkins, J.E. and Schacht, J. Sketches of Otohistory. Part 8: The emergence of vestibular science. Audiol. Neurotol. 10:185-190, 2005. doi: 10.1159/000085076
• Schacht, J. and Hawkins, J.E. Sketches of Otohistory. Part 9: Presby[a]cusis. Audiol. Neurotol. 10:243-247, 2005. doi: 10.1159/000086524
• Hawkins, J.E. and Schacht, J. Sketches of Otohistory. Part 10: Noise-induced hearing loss. Audiol. Neurotol. 10:305-309, 2005. doi: 10.1159/000087347
• Schacht, J. and Hawkins, J.E. Sketches of Otohistory. Part 11: Ototoxicity: Drug-induced hearing loss. Audiol. Neurotol. 11:1-6, 2006. doi: 10.1159/000088850
• Kong W-J., Hao, J. and Schacht, J. Sketches of Otohistory. Part 12: The history of otology in Traditional Chinese Medicine. Audiol. Neurotol. 11:145-150, 2006. doi: 10.1159/000091411

And an earlier contribution:

• Hawkins, J.E. and Schacht, J. Classics from The Laryngoscope: Smith et al.: "The Electrolytes of the Labyrinthine Fluids". Laryngoscope 107:293-297, 1997.