Auditory Biochemistry and Molecular Biology Laboratory
Hartmut Hahn, Ph.D.
Research Fellow
Phone: (734) 764-5196
Fax: (734) 764-0014
E-mail: hahnh@umich.edu
Education
- Ph.D. in biology, University of Tübingen, Germany, 1995
- Post-doctoral researcher at Dept. of Sensory Biophysics, University of Tübingen, Germany, 1995 - 1998
- Scientist with Otogene AG, Tübingen, Germany, 1998 � 2002
- Researcher at ENT-Clinic, University of Tübingen, 2002 � 2005
Hobbies
- Having a nice big family
- Playing the trombone
- Playing semi-acoustic guitars
- Birding
Research Project
Aminoglycosides are used in clinical practice as potent drugs against gram negative infections in humans. Besides a well known nephrotoxicity their side effects include damage of the inner ear. Ototoxicity is accompanied by loss of the sensory hair cell in the hearing organ which is irreversible and leads to severe impairment of hearing in patients. In my current project I make use of a mouse model of aminoglycoside-induced hearing loss. Pronounced structural changes can be observed while apoptosis occurs in organ of Corti cells. My work is focused on intracellular signaling pathways related to these changes to better understand the mechanisms of aminoglycoside action in the inner ear.
Publications
- Oliver D, Hahn H, Antz C, Ruppersberg JP, Fakler B. Interaction of permeant and blocking ions in cloned inward-rectifier K+ channels. Biophys J. 1998 May; 74(5):2318-26.
- Schulte U, Hahn H, Wiesinger H, Ruppersberg JP, Fakler B. pH-dependent gating of ROMK (Kir1.1) channels involves conformational changes in both N and C termini. J Biol Chem. 1998 Dec 18;273(51):34575-9.
- Schulte U, Hahn H, Konrad M, Jeck N, Derst C, Wild K, Weidemann S, Ruppersberg JP, Fakler B, Ludwig J. pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15298-303.
- Plontke S, Siedow N, Hahn H, Wegener R, Zenner HP, Salt AN 1D- und 3D-Computer-Simulationen zur Versuchsplanung und –Interpretation bei pharmakokinetischen Studien am Innenohr nach lokaler Medikamentenapplikation. ALTEX 21,Suppl 1/04: 77-85, (2004)
- Löwenheim H, Reichl J, Winter H, Hahn H, Simon C, Gültig K, Müller A, Zenner H.-P., Zimmermann U and Knipper M. In vitro expansion of human nasoseptal chondrocytes reveals distinct expression profiles for G1 cell cycle inhibitors for replicative, quiescent and senescent culture stages. Tissue Eng. 2005 Jan-Feb;11(1-2):64-75.
- H. Hahn, B. Kammerer, A. DiMauro, H.-P. Zenner, A. N. Salt, S. Plontke Cochlear microdialysis for quantification of dexamethasone and fluorescein entry into scala tympani during round window administration. Hear Res. 2006 Feb;212(1-2):236-44.
- Kursiv and Löwenheim H. Three-dimensional organ culture of the whole inner ear in simulated microgravity. Submitted.
