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Kresge Hearing Research Institute

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Cell Biology & Immunology Laboratory

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• Auditory Research
• Cancer Research

Auditory Research

• Zeitoun H, Beckman-Gray J, Arts A, Lansford CD, Lee D, El-Kashlan HK, Telian SA, Denny ED, Ramakrishnan A, Nair TS, Disher MJ, Sataloff RT, Fisher SG, Carey TE. Corticosteroid response and supporting cell antibody in autoimmune hearing loss. Arch Otolaryngol Head Neck Surg 131:665-672, 2005.
• Nair TS, Kozma KE, Hoefling NL, Kommareddi PK, Ueda Y, Gong T-W, Lomax MI, Lansford CD, Telian SA, Satar B, Arts HA, El-Kashlan HK, Berryhill WE, Raphael Y, Carey TE. Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss. J Neurosci 24:1772-1779, 2004.
• Yeom K, Gray J, Nair TS, Arts HA, Telian S, Disher MJ, El-Kashlan H, Sataloff RT, Fisher SG, Carey TE. Antibodies to HSP 70 in normal donors and autoimmune hearing loss patients. Laryngoscope 113:1770-1776, 2003.
• Lasak JM, Sataloff RT, Hawkshaw M, Carey TE, Lyons KM, Spiegel JR. Autoimmune inner ear disease: Steroid and cytotoxic drug therapy. Ear Nose Throat J 80:808-822, 2001.
• Carey, TE, Nair, TS, Gray, JP, Zeitoun, H, Lansford, CD, Fisher, SG, Dolan, DF, Raphael, Y, Miller, JM, Ramakrishnan, A, Lee, DJ, Denny, ED, Arts, HA, Telian, SA, El-Kashlan, H, Disher, MJ, Sataloff, RT, Yeom, K. The Search for the Inner Ear Antigen of Autoimmune Sensorineural Hearing Loss, In: New Frontiers in Immunobiology, JE Veldman, D Passali, DJ Lim (eds), Kugler Publications, The Hague, The Netherlands, pp 67-74, 2000.
• Nair TS, Prieskorn DM, Miller JM, Dolan DF, Raphael Y, Carey TE. KHRI-3 monoclonal antibody-induced damage to the inner ear: Antibody staining of nascent scars. Hear Res 129:50-60, 1999.
• Disher MJ, Ramakrishnan A, Nair TS, Miller JM, Telian SA, Arts AA, Sataloff RT, Altschuler RA, Raphael Y, and Carey TE. Human autoantibodies and monoclonal antibody KHRI-3 bind to a phylogenetically conserved inner ear supporting cell antigen. Ann NY Acad Sci 830:253-265, 1997.
• Nair TS, Prieskorn DM, Miller JM, Mori A, Gray J, and Carey TE. In vivo binding and hearing loss after intracochlear infusion of KHRI-3 antibody. Hear Res 107:93-101, 1997.
• Nair TS, Raphael Y, Dolan DF, Parrett TJ, Perlman LS, Brahmbhatt VR, Wang Y, Hou X, Gholizadeh G, Nuttall AL, Altschuler RA and Carey TE. Monoclonal antibody induced hearing loss. Hear Res 83:101-113, 1995.
• Ptok M, Carey TE and Altschuler RA. Relationship of monoclonal antibody (KHRI 3 epitope) to cochlear supporting cell microvilli in the guinea pig. Eur Arch Otorhinolaryngol 250:345-350, 1993.
• Ptok M, Nair T, Carey TE, and Altschuler RA. Distribution of KHRI-3 epitopes in the inner ear. Hear Res 66:245-252, 1993.
• Ptok M, Nair TS, Altschuler RA, Schacht J and Carey TE. Monoclonal antibodies to inner ear antigens: II. Antigens expressed in sensory cell stereocilia. Hear Res 57:79-90, 1991.
• Zajic G, Nair TS, Ptok M, Van Waes C, Altschuler RA, Schacht J and Carey TE. Monoclonal antibodies to inner ear antigens: I. Antigens expressed by supporting cells in guinea pig cochlea. Hearing Res 52:59-72, 1991.

Cancer Research

• Worden FP, Kumar B, Lee JS, Wolf GT, Cordell KG, Taylor JMG, Urba SG, Eisbruch A, Teknos TN, Chepeha DB, Prince ME, Tsien CI, D�Silva NJ, Miller TH, Wallace NE, Bauer JA, Bradford CR, Carey TE. Chemoselection as a strategy for organ preservation in advanced oropharynx cancer. Accepted, J Clin Oncol.
• Kumar B, Cordell KG, Lee JS, Worden FP, Prince ME, Tran HH, Wolf GT, Urba SG, Chepeha DB, Teknos TN, Eisbruch A, Tsien CI, Taylor JMG, D�Silva NJ, Yang, K, Kurnit DM, Miller TH, Wallace NE, Bradford CR, Carey TE. EGFR, p16, HPV Titer, Gender and Smoking as Indicators of Response to Therapy and Survival in Oropharyngeal Cancer. Accepted, J Clin Oncol.
• Bauer JA, Kumar B, Cordell KG, Lee JS, Prince ME, Tran HH, Wolf GT, Urba SG, Worden FP, Chepeha DB, Teknos TN, Eisbruch A, Tsien CI, Griffith KA, Taylor JMG, D�Silva NJ, Wang S, Wang SJ, Wolter KG, Henson B, Carey TE, Bradford CR. Targeting Apoptosis to Overcome Cisplatin Resistance: A Translational Study in Head and Neck Cancer. Accepted, Int J Radiat Oncol Biol Phys.
• Kumar B, Cordell KG, Lee JS, Prince ME, Tran HH, Wolf GT, Urba SG, Worden FP, Chepeha DB, Teknos TN, Eisbruch A, Tsien CI, Taylor JMG, D�Silva NJ, Yang K, Kurnit DM, Bradford CR, Carey TE. Response to Therapy and Outcome in Oropharyngeal Cancer Are Predicted by Biomarkers Including HPV, EGFR, Gender and Smoking. Accepted, Int J Radiat Oncol Biol Phys.
• Kanazawa T, Iwashita T, Kommareddi P, Nair T, Misawa K, Misawa Y, Ueda Y, Tono T, Carey TE. Galanin and galanin receptor 1 suppress proliferation in squamous carcinoma cells: Activation of the extracellular signal regulated kinase pathway and induction of cyclin-dependent kinase inhibitors. Oncogene, advance online publication, 26 March 2007; doi:10.38/sj.onc.1210384.
• Henson B, Li F, Coatney DD, Carey TE, Mitra RS, Kirkwood KL, D�Silva NJ. An orthotopic floor-of mouth model for loco-regional growth and spread of human squamous cell carcinoma. J Oral Pathol Med 36:363-370, 2007.
• Verhaegen M, Bauer JA, Martin de la Vega C, Wang G, Wolter KG, Brenner JC, Nikolovska-Coleska Z, Bengtson A, Nair R, Elder JT, Carey TE, Bradford CR, Wang S, SoengasMS. A novel BH3 mimetic reveals a MAPK-dependent mechanism of melanoma cell survival controlled by p53 and reactive oxygen species. Cancer Res 66(23):11348-59, 2006.
• Prince ME, Ubell ML, Castro J, Ogawa H, Ogawa T, Narayan A, Paulino A, Cole A, Wolf GT, Rubin MA, Lyons RH, Bradford CR, Carey TE. A tissue preserving approach to extracting DNA from paraffin-embedded specimens using tissue microarray technology. Head Neck 29:465-471, 2007.
• Lin CJ, Grandis JR, Carey TE, Gollin SM, Whiteside TL, Koch WM, Ferris RL, Lai SY. Head and neck squamous cell carcinoma cell lines: Established models and rational for selection. Head Neck 29:163-188, 2007.
• Wolter KG, Wang SJ, Henson BS, Wang S, Griffith KA, Kumar B, Chen J, Carey TE, Bradford CR, D’Silva NJ. (-)-Gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo. Neoplasia 8:163-172, 2006.
• Zhang Z, Mitra R, Henson B, Datta N, McCauley L, Kumar P, Lee J, Carey T, D'Silva NJ. Rap1GAP inhibits tumor growth in oropharyngeal squamous cell carcinoma. Am J Path 168:585-596, 2006.
• Mandic R, Schamberger CJ, Müller JF, Geyer M, Zhu L, Carey TE, Grénman R, Dünne AA, Werner JA.. Reduced cisplatin sensitivity of head and neck squamous cell carcinoma cell lines correlates with mutations affecting the COOH-terminal nuclear localization signal of p53. Clin Cancer Res 11:6845-6852, 2005.
• Bauer, JA, Trask, DK, Kumar, B, Los, G, Castro, J, Lee, JS-J, Chen, J, Wang, S, Bradford, CR, Carey, TE, Reversal of Cisplatin Resistance with a BH3 Mimetic, (-)-Gossypol, in Head and Neck Cancer Cells: Role of Wild-Type p53 and Bcl-xL. Mol Cancer Ther 4:1096-1104, 2005.
• Henson BS, Neubig RR, Jang I, Ogawa T, Zhang Z, Carey TE, D’Silva NJ. Galanin receptor 1 has antiproliferative effects in oral squamous cell carcinoma. J Biol Chem 280:22564-22571, 2005.
• Yang H, Yang K, Khafagi A, Tang Y, Carey TE, Opipari AW, Lieberman R, Oeth PA, Lancaster W, Klinger HP, Kaseb AO, Metwally A, Khaled H, Kurnit DM. Sensitive detection of human papilloma virus in cervical, head/ neck and schistosomiasis-associated bladder malignancies. Proc Natl Acad Sci USA 102:7683-7688, 2005.
• Akervall J, Guo X, Qian C-N, Schoumans J, Leeser B, Kort E, Cole A, Resau J, Bradford C, Carey T, Anderson H, Tennvall J, Teh TB. Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients. Clin Cancer Res 10:8204-8213, 2004.
• Oliver CL, Bauer JA, Wolter KG, Ubell ML, Narayan A, O’Connell KM, Fisher SG, Wang S, Wu X, Ji M, Carey TE, Bradford CR. In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res 10:7757-7763, 2004.
• Akervall J, Kurnit D, Adams M, Zhu B, Fisher S, Bradford C, Carey T. Overexpression of cyclin D1 correlates with sensitivity to cisplatin in squamous cell carcinoma cell lines of the head and neck. Acta Otolaryngol 124:851-857, 2004.
• Takebayashi S, Hickson A, Ogawa T, Jung K-Y, Mineta H, Ueda Y, Grénman R, Fisher SG, Carey TE. Loss of chromosome arm 18q with tumor progression in head and neck squamous cancer. Genes Chromosomes & Cancer 41:145-154, 2004.
• Raitanen M, Worsham MJ, Lakkala T, Carey TE, Van Dyke DL, Grénman R, Klemi P, Rantanen, V, Isola J, Grénman S. Characterization of 10 vulvar carcinoma cell lines by karyotyping, comparative genomic hybridization and flow cytometry. Gynecol Oncol 93:155-163, 2004.
• Mitra R, Zhang Z, Henson B, Kurnit DM, Carey TE, D'Silva NJ. Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: Nuclear translocation of GTP-bound active form. Oncogene 22:6243-6256, 2003.
• Sisk EA, Bradford CR, Carey TE, Paulino A, Robertson E. Epstein-Barr virus detected in a head and neck squamous cell carcinoma cell line derived from an immunocompromised patient. Arch Otolaryngol Head Neck Surg 129:1115-1124, 2003.
• D’Silva NJ, Mitra RS, Zhang Z, Kurnit DM, Babcock CR, Polverini PJ, Carey TE. Rap1, a small GTP-binding protein is upregulated during arrest of proliferation in human keratinocytes. J Cellular Physiol 196:532-540, 2003.
• Bradford CR, Zhu S, Ogawa H, Ogawa T, Ubell M, Narayan A, Johnson G, Wolf GT, Fisher SG, Carey TE. p53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines. Head Neck 25:654-661, 2003.
• Akervall J, Bockmühl U, Petersen I, Yang K, Carey TE, Kurnit DM. The gene ratios c-MYC:cyclin-dependent kinase (CDK)N2A and CCND1 / CDKN2A correlate with poor prognosis in squamous cell carcinoma of the head and neck. Clin Cancer Res 9:1750-1755, 2003.
• Worsham MJ, Pals G, Schouten JP, Van Spaendonk RM, Concus A, Carey TE, Benninger MS. Delineating genetic pathways of disease progression in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 129:702-708, 2003.
• Hauser U, Balz V, Carey TE, Grenman R, Van Lierop A, Scheckenbach K, Bier H. Reliable detection of p53 aberrations in squamous cell carcinoma of the head and neck requires transcript analysis of the entire coding region. Head Neck 24:868-873, 2002.
• Sisk EA, Soltys SG, Zhu S, Fisher SG, Carey TE, Bradford CR. Human papillomavirus and p53 mutational status as prognostic factors in head and neck carcinoma. Head Neck 24:841-849, 2002.
• Teknos TN, Cox C, Yoo S, Chepeha DB, Wolf GT, Bradford CR, Carey TE, Fisher SG. Elevated serum vascular endothelial growth factor and decreased survival in advanced laryngeal carcinoma. Head Neck 24:1004-1011, 2002.
• Zeng Q, Chen S, You Z, Yang F, Carey TE, Saims D, Wang CY. Hepatocyte growth factor inhibits anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NFkappa B. J Biol Chem 277:25203-25208, 2002.
• Mertens, Fredrik and Carey, Thomas E. Solid Tumor Cytogenetics. In: Clinical Laboratory Medicine (2nd Edition), KD McClatchey (ed), Lippincott Williams & Wilkins, Philadelphia, PA, pp 704-730, 2002.
• Zou CP, Youssef EM, Zou CC, Carey TE, Lotan R. Differential effects of chromosome 3p deletion on the expression of the putative tumor suppressor RAR beta and on retinoid resistance in human squamous carcinoma cells. Oncogene 20:6820-6827, 2001.
• Carey TE and Wennerberg J. Cellular and Molecular Biology of the Cancer Cell. In: Head and Neck Pathology: With Clinical Correlations. Y-S Fu, BM Wenig, E Abemayor, and BL Wenig (eds), Churchill Livingstone, New York, NY, pp 3-37, 2001.
• Carey TE and Bradford CR. Molecular Biology of Laryngeal Cancer. In: Diseases of the Larynx. A Ferlito (ed), Arnold Publishing, London (published in the US by Oxford University Press, New York) pp. 533-539, 2000.
• Lansford C, Grenman R, Bier H, Somers KD, Kim S-Y, Whiteside TL, Clayman G and Carey TE. Head and Neck Cancers. In: Human Cell Culture Vol 2, Cancer Cell Lines Part 2. JRW Masters and B Palsson (eds), Kluwer Academic Press, Dordrecht (Holland), pp. 185-255, 2000.
• Kim SH, Carey TE, Liebert M, Yoo SJ, Kwon HJ, Kim SY. Characterization of AMC-HN-9, a cell line established from an undifferentiated carcinoma of the parotid gland: Expression of α6ß4 with the absence of BP180 and 230. Acta Otolaryngol 120:660-666, 2000.
• Takebayashi S, Ogawa T, Jung KY, Muallem A, Mineta H, Fisher S.G., Grenman R, Carey TE. Identification of new minimally lost regions on 18q in head and neck squamous cell carcinoma. Cancer Res 60:3397-3403, 2000.
• Sun JD, Weatherly RA, Koopmann CF Jr, Carey TE. Mucosal swabs detect HPV in laryngeal papillomatosis patients but not family members. Int J Pediatr Otorhinolaryngol 53:95-103, 2000.
• Sisk EA, Bradford CR, Jacob A, Yian CH, Staton KM, Tang G, Harris MO, Carey TE, Lancaster WD, Gregoire L. Human papillomavirus infection in "e;young"e; versus "e;old"e; patients with squamous cell carcinoma of the head and neck. Head Neck 22:649-657, 2000.