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Kresge Hearing Research Institute

Department of Otolaryngology

Auditory Anatomy Menu

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  • - Tinnitus and Auditory Processing Disorders
    •   - Activity Dependent Plasticity
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Auditory Anatomy Laboratory

Recent Publications

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• Neurotransmission and Plasticity
• Stem Cells and Tissue Engineering
• Stress Response and Protection

Neurotransmission and Plasticity

Peer Reviewed Publications (1995-present)

• Cui Y, Holt AG, Lomax CA, Altschuler RA,  Deafness-associated changes in 2-pore domain K+ channel subunits in the rat inferior colliculus, Neuroscience, 2007 Jul 17; [Epub ahead of print] PMID: 17884299
• Holt AG, Asako M, Duncan RK, Lomax CA, Juiz JM, Altschuler RA, Deafness associated changes in expression of two-pore domain potassium channels in the rat cochlear nucleus, Hearing Research, 2006
• Buras, ED, Holt, AG, Griffith, RD, Asako, M, Altschuler, RA, Changes in glycine immunoreactivity in the rat SOC following deafness, J. Comp. Neurol., 494:179-89, 2006.
• Tong L, Altschuler RA, Holt AG, Tyrosine hydroxylase in the rat auditory midbrain: Distribution and changes following deafness, Hearing Res. 206:28-41, 2005.
• Holt AG, Asako A, Lomax, CA, MacDonald J, Tong L, Lomax MI, Altschuler, RA, Deafness related plasticity in the inferior colliculus: Gene expression profiling following removal of peripheral activity, J. Neurochem, 93:1069-86, 2005.
• Asako,M, Holt, AG, Griffith, RD, Buras, ED, Altschuler, RA, Deafness-related changes in glycine-immunoreactive staining in the rat cochlear nucleus, J. Neurosci Res, 81:102-109. 2005.
• Cho Y, Gong T-WL, Stover T, Lomax MI and Altschuler RA: Gene expression profiles in the rat auditory system, JARO, 3:54-57, 2002
• Shiraishi S, Shiraishi Y, Oliver DW & Altschuler RA: Expression of GABAA Receptor Subunits in the Rat Central Nucleus of the Inferior Colliculus, Molecular Brain Research. 96:122-32, 2001.
• Nakagawa H, Sato, K., Shiraishi S, Kuriyama H & Altschuler RA: NMDAR1 Isoforms in the Rat Superior Olivary Complex and Changes after Unilateral Cochlear Ablation. Molecular Brain Research, Molecular Brain Research, 77:246-257, 2000.
• Sato K, Shiraishi S, Nakagawa H, Kuriyama H, Altschuler RA: Diversity and plasticity in amino acid receptor subunits in the rat auditory brain stem, Hearing Research 147:136-144, 2000.
• Sato K, Kuriyama H & Altschuler RA: Expression of glycine receptor subunit mRNAs in the rat cochlear nucleus, Hearing Research 144:47-52, 2000.
• Shore SE, Vass Z, Wys NL, Altschuler RA, Trigeminal ganglion innervates the auditory brain stem, J. Comp Neurol, 419:271-285, 2000.
• Sato K, Nakagawa H, Kuriymama H and Altschuler RA: Differential distribution of NMD receptor subunit mRNA in the rat superior olivary complex. Neuroscience, 89:839-853, 1999.
• Fessenden JD, Altschuler RA, Seasholtz AF & Schacht J. The nitric oxide/cyclic GMP pathway in the peripheral and central auditory system of the rat. J Comp Neurol 404:52-63, 1999.
• Saito H, Miller JM, Pfingst BE, Altschuler RA: Fos immunoreactivity in the auditory brain stem evoked by bipolar intracochlear electrical stimulation: Effects of current level and pulse duration. Neuroscience, 91:139-161, 1999
• Munemoto Y. Kuriyama H. Doi T. Sato K. Matsumoto A. Sugatani J. Cho H. Komeda M. Altschuler RA. Kitajiri M. Mishina M. Yamashita T. Auditory pathway and auditory brainstem response in mice lacking NMDA receptor epsilon 1 and epsilon 4 subunits. Neuroscience Letters. 251:101-4, 1998
• Sato K, Kuriyama H & Altschuler RA: Differential distribution of NMDA receptor subunit mRNA in the rat cochlear nucleus. Microscopy Research and Technique 41:217-223, 1998.
• Juiz JM, Helfert RH, Bonneau JM, Wenthold RJ, Altschuler RA: Three classes of inhibitory amino acid terminals in the cochlear nucleus of the guinea pig. J. Comp Neurol., 373:11-26, 1996.
• Juiz JM. Helfert RH. Bonneau JM. Campos ML. Altschuler RA. Distribution of glycine and GABA immunoreactivities in the cochlear nucleus: quantitative patterns of putative inhibitory inputs on three cell types. Journal fur Hirnforschung. 37(4):561-74, 1996
• Juiz JM, Campos ML, Helfert RH & Altschuler RA: Silver intensification of immunogold on ultrathin plastic sections applied to the study of the neuronal distribution of GABA and glycine. Journal fur Hirnforschung. 37(1):51-6, 1996.
• Sato K, Kuriyama H & Altschuler RA: Expression of glycine receptor subunits in the cochlear nucleus and superior olivary complex using non-radioactive in situ hybridization. Hearing Res. 91:7-18, 1995.
• Lesperance MM, Helfert RH & Altschuler RA: Deafness induced cell size changes in rostral AVCN of the guinea pig. Hearing Research,86:77-81, 1995
• Bledsoe SC, Nagase S, Miller JM & Altschuler RA: Deafness-induced plasticity in the mature central auditory system. Neuroreport, 7: 225-229, 1995.

Chapters and Reviews

• Altschuler, RA, Holt, AG, Asako,M, Lomax, CA, Lomax, MI, Juiz J , Molecular mechanisms in deafness-related audutory brain stem plasticity, in "Plasticity of the Central Auditory System and Processing of Complex Acoustic Signals, J. Syka and M. Merzenich editors, 2004.
• Altschuler RA, Sato K, Dupont J, Bonneau JB & Nakagawa H: NMDA & glycine receptors in the auditory brain stem. Diversity and changes with deafness. In: Acoustic Signal Processing in the Central Auditory System, Sykka J ed, Plenum Press, 1997 pp 193-202.
• Bledoe SC, Nagase S, Altschuler RA and Miller JM: Changes in the Central Auditory System with Deafness and return of activity via a cochlear prostheses. In: Acoustic Signal Processing in the Central Auditory System, Sykka J ed, Plenum Press, 1997 pp 513- 528.
• Miller JM, Altschuler RA, Dupont J, Lesperance M and Tucci D: Consequences of deafness and electrical stimulation on the auditory system, in Auditory Plasticity and Regeneration, Salvi RJ, Henderson D, Fiorino F and Colletti V eds, Tieman Med Publishers, NY, 1996. pp 378-391.
• Altschuler RA, Raphael Y, Dupont J, Sato K and Miller JM: Active mechanisms in the response of the auditory system to over or under stimulation. in Active Hearing, Flock A, Ottoson D & Ulfendahl M eds, Elsevier, 239-256, 1995.

Stem Cells and Tissue Engineering

Peer Reviewed Publications (1995-present)

• Glueckert R, Bitsche M, Miller JM, Zhu Y1, Prieskorn DM, Altschuler RA, Schrott-Fischer A, De-afferentation associated changes in afferent and efferent processes in the guinea pig cochlea and afferent regeneration with chronic intrascalar Brain-Derived Neurotrophic Factor and Acidic Fibroblast Growth Factor, J. Comp. Neurology, in press
• Miller JM, LePrell CG, Prieskorn DM, Wys NL, Altschuler RA,  Delayed Neurotrophin Treatment Following Deafness Rescues Spiral Ganglion Cells from Death and Promotes Regrowth of Auditory Nerve Peripheral Processes:  Effects of Brain-Derived Neurotrophic Factor and Fibroblast Growth Factor, J NeuroSci Research
• Maruyama J,  Yamagata T, Ulfendahl M,  Bredberg G, Altschuler RA, Miller JM, Effects of antioxidants on auditory nerve function and survival in deafened guinea pigs,  Neurobiology of Disease,  25(2):309-18, 2007
• Yamagata T, Miller JM, Ulfendahl M, Olivius NP, Altschuler RA, Pyykko I and Bredberg G, Delayed neurotrophic treatment preserves nerve survival and electrophysiological responsiveness in neomycine-deafened guinea pigs, J. Neurosci Res. 78:75-86, 2004.
• Nagase S, Mukaida M, Miller JM and Altschuler RA, Neonatal deafening causes changes in Fos protein induced by cochlear electrical stimulation. J. Neurocytology 32:353-361, 2003.
• Miller AM, Prieskorn DM, Altschuler RA and Miller JM, Mechanism of electrical stimulation-induced neuroprotection: Effects of verapimal on protection of primary auditory afferents, Brain Research, 966-218-30, 2003.
• Cui X, Wiler J, Dzaman M, Altschuler RA, Martin DC, In vivo studies of polypyrrole/peptide coated neural probes, Biomaterials. 24:777-87, 2003.
• Shinohara T, Bredberg G, Ulfendahl M, Pyykkö I, Olivius NP, Kaksonen R, Lindström B, Altschuler R, Miller JM: Neurotrophins restore auditory function following deafness - implications for clinical use of cochlear prostheses, PNAS, 99:1657-60, 2002.
• Kansaki S, Stover T, Kawamoto K, Prieskorn DM, Altschuler RA, Miller JM & Raphael Y, Glial cell line-derived neurotrophic factor and chronic electrical stimulation prevent VIII cranial nerve degeneration following denervation. J. Comp Neurol 454:350-360, 2002.
• Cho Y, Gong T-WL, Stover T, Lomax MI and Altschuler RA: Gene expression profiles in the rat auditory system, JARO, 2002.
• Lomax MI, Huang L, Cho Y, Gong T-WL, Altschuler RA: Differential Display and Gene Arrays to Examine Auditory Plasticity, Hearing Research, 147:293-302, 2000.
• Nagase S, Dupont J, Miller JM, Lim HH & Altschuler RA: Deafness related changes in fos expression from cochlear electrical stimulation in the rat inferior colliculus, Hearing Research, 147:242-250, 2000.
• Nakagawa H, Sato, K., Shiraishi Y, Kuriyama H & Altschuler RA: NMDAR1 Isoforms in the Rat Superior Olivary Complex and Changes after Unilateral Cochlear Ablation. Molecular Brain Research, 77:246-257, 2000.
• Sato K, Shiraishi S, Nakagawa H, Kuriyama H, Altschuler RA: Diversity and plasticity in amino acid receptor subunits in the rat auditory brain stem, Hearing Research 147:136-144, 2000.
• Saito H, Miller JM, Pfingst BE, Altschuler RA: Fos immunoreactivity in the auditory brain stem evoked by bipolar intracochlear electrical stimulation: Effects of current level and pulse duration. Neuroscience, 91:139-161, 1999
• Griffith, A. J., Ji, W., Prince, M. E., Altschuler, R. A. and M. H. Meisler, Optic, olfactory and vestibular dysmorphogenesis in the homozygous mouse insertional mutant Tg9257. J. Craniofac. Genet. and Devel. Biol. 19:157-163, 1999.
• Miller JM, Dolan DF, Raphael Y, Altschuler RA, Interactive effects of aging with noise induced hearing loss. Scandinavian Audiol 27:53-61, Suppl 48, 1998
• Miller JM, Chi DH, Kruszka P, Raphael Y & Altschuler RA: Neurotrophins can enhance spiral ganglion cell survival after inner hair cell loss. Intl. J. Dev. Neuroscience 15:631-643, 1997.
• Mitchell A, Miller JM, Finger P, Heller J and Altschuler RA: Effects of chronic high rate electrical stimulation on the cochlea and eighth nerve in the deafened guinea pig. Hearing Research 105:30-43, 1997
• Forrest D, Erway LC, Ng L, Altschuler R & Curran T: Thyroid hormone receptor beta is essentiual for development of auditory function. Nature Genetics 13:354-357, 1996.
• Disher MJ, Ramakrishnan A, Nair TS, Miller JM, Telian SA, Arts HA, Sataloff RT, Altschuler RA, Raphael Y and Carey TE: Human autoantibodies and monoclonal antibody KHRI-3 bind to a phylogenetically conserved inner ear supporting cell antigen. Ann NY Acad Sci 830:253-265, 1997
• Lesperance MM, Helfert RH & Altschuler RA: Deafness induced cell size changes in& rostral AVCN of the guinea pig. Hearing Research,86:77-81, 1995
• Miller JM & Altschuler RA: Effectiveness of different electrical stimulation conditions in preservation of spiral ganglion cells following deafness. Annals Otol. Rhinol. & Laryngol, 166:57-60, 1995.
• Bledsoe SC, Nagase S, Miller JM & Altschuler RA: Deafness-induced plasticity in the mature central auditory system. Neuroreport, 7:225-229, 1995

Chapters and Reviews

• Altschuler RA, Raphael Y, Schacht J, Martin, D, Anderson DJ & Miller JM, Protection and Repair of Hearing, in Principles of Tissue Engineering, Third Edition,  Lanza R, Langer R & Vacanti J (editors), Academic Press, CA, pp 751-762, 2006.
• Raphael Y & Altschuler RA, Structure and innervation of the cochlea, Brain Research Bulletin. 60:397-422, 2003.
• Miller JM, Miller AL, Yamagata T, Bredberg G, Altschuler RA, Protection and regrowth of the auditory nerve after deafness, Audiology & Neurotology, 2002
• Altschuler RA, Raphael Y, Schacht J, Anderson DJ & Miller JM, Protection and Repair of Hearing, in Principles of Tissue Engineering, Second Edition, Lanza R, Langer R & Vacanti J (editors), Academic Press, CA, pp 751-762, 2000.
• Altschuler, RA, Cho Y, Ylikoski J, Pirvola U, Magal, E and Miller JM. Rescue and regrowth of the auditory nerve by neurotrophic factors following deafferentation. Annals of the New York Academy of Sciences, 884:305-311, 1999
• Miller, AM, Yamasoba T and Altschuler RA: Hair cell and spiral ganglion neuron preservation and regeneration - influence of growth factors, Current Opinions in Otolaryngology, Head & Neck Surgery, 6:301-307, 1998.
• Altschuler RA, Sato K, Dupont J, Bonneau JB & Nakagawa H: NMDA & glycine receptors in the auditory brain stem. Diversity and changes with deafness. In: Acoustic Signal Processing in the Central Auditory System, Sykka J ed, Plenum Press, 1997 pp 193-202.
• Bledsoe SC, Nagase S, Altschuler RA and Miller JM: Changes in the Central Auditory System with Deafness and return of activity via a cochlear prostheses. In Acoustic Signal Processing in the Central Auditory System, Sykka J ed, Plenum Press, 1997 pp 513- 528.
• Miller J, Altschuler R, Henny GC: Hearing Assistance, in Principles of Tissue Engineering,z Lanza R, Langer R & Chick W, Academic Press, CA, 1997 pp 663-669
• Raphael Y, Adler HJ, Neimiec and Altschuler RA: Trauma, repair and regeneration: The role of supporting Cells. in Auditory Plasticity and Regeneration, Salvi RJ, Henderson D, Fiorino F and Colletti V eds, Tieman Med Publishers, NY, 1996 pp 30-42.
• Miller JM, Altschuler RA, Dupont J, Lesperance M and Tucci D: Consequences of deafness and electrical stimulation on the auditory system, in Auditory Plasticity and Regeneration, Salvi RJ, Henderson D, Fiorino F and Colletti V eds, Tieman Med Publishers, NY, 1996. pp 378-391.
• Altschuler RA, Lim HH, Ditto J, Dolan D and Raphael Y: Protective mechanisms in the cochlea: Heat shock proteins. in Auditory Plasticity and Regeneration, Salvi RJ, Henderson D, Fiorino F and Colletti V eds, Tieman Med Publishers, NY, 1996 pp 202-212.
• Altschuler RA, Raphael Y, Dupont J, Sato K and Miller JM: Active mechanisms in the response of the auditory system to over or under stimulation. in Active Hearing, Flock A, Ottoson D & Ulfendahl M eds, Elsevier, 1995, 239-256.

 

Stress Response and Protection

Peer Reviewed Publications (1995-present)

• Fairfield, DA, Margaret I. Lomax, MI, Gary A. Dootz, GA, Chen, S, Galecki, TA, Benjamin, IJ, David F. Dolan, DF, Altschuler, RA, Heat shock factor 1 (Hsf1) deficient mice exhibit decreased recovery of hearing following noise overstimulation, J. Neurosci Res. 81:589-596, 2005.
• Fairfield, D.A., Kanicki, A.C., Lomax, M.I., Altschuler, R.A., Induction of heat shock protein 32 (Hsp32) in the rat cochlea following hyperthermia. Hear. Res. 188, 1-11. 2004
• Yamagata T, Miller JM, Ulfendahl M, Olivius NP, Altschuler RA, Pyykko I and Bredberg G, Delayed neurotrophic treatment preserves nerve survival and electrophysiological responsiveness in neomycine-deafened guinea pigs, J. Neurosci Res. 78:75-86, 2004
• Stover, T, Wissel, K, Averbeck, T, Lenarz, T, Altschuler, RA, .Characterisation of the gene expression profiles in the inner ear and the colliculus inferior of normal and deafened rats by gene-array-technology, Laryngorhinootologie 83:597-605, 2004
• Cho Y, Gong T-W, Kanicki A, Altschuler RA & Lomax MI, Noise overstimulation induces early immediate genes in the Rat Cochlea, Molecular Brain Research, 130:134-148, 2004.
• Fairfield DA, Kanicki AC, Lomax MI & Altschuler RA: Expression and localization of heat shock factor (HSF) 1 in the rodent cochlea, Hearing Research, 173:109-118, 2002.
• Leonova, EV, Fairfield, DA, Lomax, MI, R.A. Altschuler, RA: Constitutive expression of HSP 27 in the rat cochlea, Hearing Research. 163:61-70, 2002.
• Shinohara T, Bredberg G, Ulfendahl M, Pyykk& ouml; I, Olivius NP, Kaksonen R, Lindstr& ouml;m B, Altschuler R, Miller JM: Neurotrophins restore auditory function following deafness - implications for clinical use of cochlear prostheses, PNAS, 2002.
• Stover T, Nam Y-J, Gong T-W L, Hartman SS, Lomax MI & Altschuler RA: Glial-line derived neurotrophic factor (GDNF) and its receptor complex are expressed in the auditory nerve of the mature rat cochlea, Hearing Research 155:143-51, 2001.
• Yamasoba T, Altschuler RA, Raphael Y, Miller AM, Shoji F & Miller JM, Absence of hair cell protection by exogenous FGF-1 and FGF-2 delivered to the guinea pig cochlea in vivo. Noise and Health 3:65-78, 2001.
• Ohinata Y, Miller JM, Altschuler RA, Schacht J: Intense noise exposure induces information of vasoactive lipid peroxidation products in the cochlea, Brain Research 29:163-73, 2000.
• Stover T, Nam Y-J, Gong T-W L, Hartman SS, Lomax MI & Altschuler RA: Glial-line derived neurotrophic factor (GDNF) and its receptor complex are expressed in the auditory nerve of the mature rat cochlea, Hearing Research155:143-51, 2001
• Shoji F, Yamasoba T, Magal E, Dolan DF, Altschuler RA, Miller JM, Glial cell line-derived neurotrophic factor (GDNF) protects auditory hair cells in the guinea pig cochlea from noise stress in vivo. Hearing Research, 142:41-55, 2000.
• Nam, Y-J, Stover T, Hartman SS, and Altschuler RA: Upregulation of glial-line derived neurotrophic factor in the rat cochlea following noise, Hearing Research, 146:1-6, 2000.
• Shoji, F, Miller, A.M., Yamasoba, T, Altschuler, RA, Miller, JM: Differential protective effects of neurotrophins in the attenuation of noise-induced hair cell loss, Hearing Reseach, 146:134-142, 2000.
• Stover, T, Gong T-W L, Cho Y, Altschuler RA & Lomax MI, Expression of the GDNF-family members and their receptors in the mature rat cochlea, Molecular Brain Research, 76:25-35, 2000.
• Miller JM, Dolan DF, Raphael Y, Altschuler RA, Interactive effects of aging with noise induced hearing loss. Scandinavian Audiol 27:53-61, Suppl 48, 1998
• Ylikoski J, Pirvola U, Suvanto P, Liang X-Q, Virkkala J, Magal E, Altschuler RA, Miller JM, and Saarma M: Guinea pig auditory neurons are protected by GDNF from degeneration after noise trauma, Hear Res 124:17-26, 1998

Chapters and Reviews

• LePrell, C, Dolan D, Fairfield D, Lomax M, Schacht J, Miller J and Altschuler R, Pathways for Protection from Noise Induced Hearing Loss, Noise and Health, 5:20, 1-17, 2003.
• Altschuler RA, Fairfield D, Cho Y, Leonova E, Benjamin I, Miller JM, Lomax MI, Stress pathways in the rat cochlea and potential for protection from acquired deafness, Audiology & Neurotology, 7:152-156, 2002.
• Lomax MI, Huang L, T-W Gong, Cho Y & Altschuler RA: Differential gene expression following noise trauma in birds and mammals, Noise & Health, 3:19-36, 2001
• Altschuler RA, Raphael Y, Schacht J, Anderson DJ & Miller JM, Protection and Repair of Hearing, in Principles of Tissue Engineering, Second Edition, Lanza R, Langer R & Vacanti J (editors), Academic Press, CA, pp 751-762, 2000
• Altschuler RA, Miller JM, Raphael Y, Schacht J. Strategies for protection of the inner ear from noise induced hearing loss. In: Cochlear Pharmacology and Noise Trauma. Prasher DK, Canlon B (eds) Noise Research Network Publications, London, pp 98-112, 1999
• Miller, JM, Yamasoba T, Shoji F, Altschuler RA: Neurotrophin and antioxidant protection of the inner ear from noise induced damage. In: Recent Advances in Inner Ear Research. Kanehara & Co, 1998.
• Miller, AM, Yamasoba T and Altschuler RA: Hair cell and spiral ganglion neuron preservation and regeneration - influence of growth factors, Current Opinions in Otolaryngology, Head & Neck Surgery, 6:301-307, 1998.
• Raphael Y, Adler HJ, Nieimic A and Altschuler RA: Trauma, repair and regeneration: The role of supporting Cells. in Auditory Plasticity and Regeneration, Salvi RJ, Henderson D, Fiorino F and Colletti V eds, Tieman Med Publishers, NY, 1996 pp 30-42.
• Lim HH, Miller JM, Dolan D, Raphael Y & Altschuler RA: Noise-induced expression of heat shock proteins in the cochlea, in Scientific Basis of Noise-Induced Hearing Loss, Axellsen, Henderson, Hamernik eds, Chernow, NY, 1996 pp 43-49
• Altschuler RA, Lim HH, Ditto J, Dolan D and Raphael Y: Protective mechanisms in the cochlea: Heat shock proteins. in Auditory Plasticity and Regeneration, Salvi RJ, Henderson D, Fiorino F and Colletti V eds, Tieman Med Publishers, NY, 1996 pp 202-2
• Altschuler RA, Raphael Y, Dupont J, Sato K and Miller JM: Active mechanisms in the response of the auditory system to over or under stimulation. in Active Hearing, Flock A, Ottoson D & Ulfendahl M eds, Elsevier, 1995, 239-256.